• The investigational compound may potentially be used as a therapy for the neurological disease, multiple system atrophy (MSA). MSA is characterized by involuntary muscle movements, slow movement, inflexible muscles, disturbed balance and nervous system problems.
• This is a clinical trial with a radioactive (14C) labeled investigational compound. Radioactively labeling a compound is done to be able to study how quickly and to what extent the compound is absorbed, converted and excreted by the body. The radioactivity disappears from the body at the same time as the compound through the feces, urine and/or breath. The compound has a radiation burden which is less than from the natural background radiation that you are exposed to in the Netherlands in 1 month. This background radiation is released from space, soil, air, water, food and construction materials. To measure radioactivity levels in your body, blood, urine and feces will be collected during the trial.
• The compound will be administered as capsules via the mouth, once a day for 15 days.

• You are a healthy male.
• You are at least 18 and at most 65 years old.
• Your Body Mass Index (BMI) is at least 18.0 and at most 32.0 kg/m2. 
• You do not smoke and you do not use any nicotine-containing products.

Note:

• You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the admission in the research facility (counting from the follow-up visit). This may be longer for certain trials. Contact us for more information.
• You can only participate in this trial if you have not participated in another trial with a radioactive (14C) labeled compound in the past 12 months. An exception to this are trials with a very low dose of radioactivity, which had a negligible radiation burden. Please reach out to us for more information.
• To determine if you are suitable to participate in this trial, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.
• You can only participate if you meet one of the following conditions:
  • You are using a condom in combination with an additional contraception method used by your female partner (such as the pill or an IUD);
  • You have been sterilized or your female partner is sterilized or has passed the menopause (no periods for at least 12 months);
  • You are not sexually active according to your lifestyle;
  • You are only sexually active with a partner of the same sex.

The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 23 days (22 nights). Depending on the amount of radioactivity that has left your body after 23 days, you may have to return for at most two 24-hour visits (1 night). The follow-up visit will take place 7 – 9 days after your last departure from the research facility.

Note: You must be available for all dates to be able to participate in this clinical trial.