• You are a healthy male.
• You are at least 18 and at most 55 years old.
• Your weight is at least 60 kg and at most 100 kg and your Body Mass Index (BMI) is at least 18.5 and at most 29.9 kg/m2. 
• Both non-smokers and light or occasional smokers are allowed to participate (at most 5 cigarettes per day). During your stay in the research facility, smoking is not permitted.

Note:

• You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the first compound administration in this clinical trial (counting from the follow-up visit).
• To determine if you are suitable to participate in this trial, you will undergo a medical screening.

You can only participate if you meet one of the following conditions:

• You are using a condom in combination with an additional contraception method used by your female partner;
• You have been sterilized or your female partner is sterilized or has passed the menopause (no periods for at least 12 months);
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

The trial consists of 2 periods during each of which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 9 days (8 nights). Each period is followed by 4 short visits. The follow-up visit will take place during the final short visit.

Note: You must be available for all dates to be able to participate in this clinical trial. The current dates of the clinical trial will be published on our website.