• You are a healthy male or female.
• You are at least 18 and at most 55 years old.
• Your Body Mass Index (BMI) is at least 18.5 and at most 30.0 kg/m2. 
• You do not smoke and do not use any nicotine-containing products.

As a female you can only participate if you are not pregnant, not breast feeding and meet one of the following conditions:

• You are using hormonal contraception (for example the contraceptive pill or intra-uterine device containing hormones);
• You are using a copper intra-uterine device;
• You have passed the menopause (no periods for at least 12 months);
• You have been sterilized or your male partner has been sterilized;
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

As a male you can only participate if you meet one of the following conditions:

• You are using a condom with your female partner;
• Your female partner is sterilized or has passed the menopause (no periods for at least 12 months);
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

Note: 
You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the screening of this clinical trial (counting from the follow-up visit). To determine if you are suitable to participate in this trial, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.

The trial consists of 2 periods during which you will stay in the research facility in Groningen (location van Swietenlaan 6). Both periods consist of 3 days (2 nights). Each period is followed by 7 short visits. The follow-up visit will take place during the last short visit of the second period.

Note: You must be available for all dates to be able to participate in this clinical trial. The current dates of the clinical trial will be published on our website.